Citation: Hong-Feng Shen, Xi Chen, Pin Liao, Xu-Shen Shao, Zhong Li, Xiao-Yong Xu. Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring[J]. Chinese Chemical Letters, ;2015, 26(5): 509-512. doi: 10.1016/j.cclet.2015.03.017 shu

Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

Hong-Feng Shen ^a ,
Xi Chen ^a ,
Pin Liao ^a ,
Xu-Shen Shao ^a,b ,
Zhong Li ^a,b ,
Xiao-Yong Xu ^a,b,,

1.
a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
2.
b Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

Corresponding author: Xiao-Yong Xu,
Received Date: 23 December 2014
Available Online: 28 January 2015
Fund Project: This work was supported by National Key Technology R&D Program of China (No. 2011BAE06B01). (No. 2011BAE06B01)

Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds 5a-c achieved good insecticidal activity against Aphis craccivora, and compound 5h exhibited good activity against Nilaparvata lugens.
- Neonicotinoid,
- Pyrrole,
- Dihydropyrrole,
- Insecticidal activity
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