Citation: John T. King, Evan J. Arthur, Derek G. Osborne, Charles L. Brooks Ⅲ, Kevin J. Kubarych. Biomolecular hydration dynamics probed with 2D-IR spectroscopy: From dilute solution to a macromolecular crowd[J]. Chinese Chemical Letters, ;2015, 26(4): 435-438. doi: 10.1016/j.cclet.2015.03.005 shu

Biomolecular hydration dynamics probed with 2D-IR spectroscopy: From dilute solution to a macromolecular crowd

1.
a Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA;
2.
b LSA Biophysics, University of Michigan, Ann Arbor, MI 48109, USA

Corresponding author: Kevin J. Kubarych,
Received Date: 26 November 2014
Available Online: 9 January 2015
Fund Project: This work has been supported by the National Science Foundation (No. CHE-0748501) (No. CHE-0748501) the National Institutes of Health (No. RR012255) (No. RR012255)

Although it is well known that water is essential for biological function, it has been a challenge to determine how water behaves near biomacromolecular interfaces, and what role water plays in influencing the dynamics of the biochemical machinery. By adopting a vibrational labeling strategy coupled with ultrafast two-dimensional infrared (2D-IR) spectroscopy, it has recently become possible to study hydration dynamics, site specifically at the surface of proteins and model membranes. We review our recent progress in measuring hydration dynamics in contexts ranging from small-molecule solutes to biomacromolecules in dilute, viscous, and crowded environments.
- Protein hydration dynamics,
- Membrane dynamics,
- Ultrafast infrared spectroscopy
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