Citation: Alexander K. Wolf, Yu Qin, Terry C. Major, Mark E. Meyerhoff. Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings[J]. Chinese Chemical Letters, ;2015, 26(4): 464-468. doi: 10.1016/j.cclet.2015.03.002 shu

Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

1.
a Department of Chemistry, University of Michigan, Ann Arbor, MI, USA;
2.
b Department of Chemistry, Nanjing University, Nanjing 210093, China;
3.
c Department of Surgery, University of Michigan, Ann Arbor, MI, USA

Corresponding author: Mark E. Meyerhoff,
Received Date: 12 December 2014
Available Online: 15 January 2015
Fund Project:

In this work, nitric oxide (NO) release coatings designed for intravenous amperometric glucose sensors are optimized through the use of a polylactic acid (PLA) layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An Elast-Eon E2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor's linear detection range toward glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.
- Nitric oxide release coatings,
- Glucose sensors,
- Polylactic acid layer,
- Quantitative glucose measurements
1. [1]
  [1] M.S. Boyne, D.M. Silver, J. Kaplan, C.D. Saudek, Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor, Diabetes 52 (2003) 2790-2794.
2. [2]
  [2] N. Wisniewski, M. Reichert, Methods for reducing biosensor membrane biofouling, Colloid Surf. B: Biointerfaces 18 (2000) 197-219.
3. [3]
  [3] M. Frost, M.E. Meyerhoff, In vivo chemical sensors: tackling biocompatibility, Anal. Chem. 78 (2006) 7370-7377.
4. [4]
  [4] M.W. Vaughn, L. Kuo, J.C. Liao, Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model, Am. J. Physiol. 274 (1998) H2163-H2176.
5. [5]
  [5] Q. Yan, T.C. Major, R.H. Bartlett, M.E. Meyerhoff, Intravascular glucose/lactate sensors prepared with nitric oxide releasing poly (lactide-co-glycolide)-based coatings for enhanced biocompatibility, Biosens. Bioelectron. 26 (2011) 4276-4282.
6. [6]
  [6] Q. Yan, B. Peng, S. Gang, et al., Measurement of tear glucose levels with amperometric glucose biosensor/capillary tube configuration, Anal. Chem. 83 (2011) 8341-8346.
7. [7]
  [7] M.M. Batchelor, S.L. Reoma, P.S. Fleser, et al., More lipophilic dialkyldiaminebased diazeniumdiolates: synthesis, characterization, and application in preparing thromboresistant nitric oxide release polymeric coatings, J. Med. Chem. 46 (2003) 5153-5161.
8. [8]
  [8] D.S. Bindra, Y.N. Zhang, G.S. Wilson, et al., Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring, Anal. Chem. 63 (1991) 1692-1696.
9. [9]
  [9] R. Gifford, M.M. Batchelor, Y. Lee, et al., Mediation of in vivo glucose sensor inflammatory response via nitric oxide release, J. Biomed. Mater. Res. A 75A (2005) 755-766.
10. [10]
  [10] I. Carelli, I. Chiarotto, I. Curulli, G. Palleschi, Electropolymerization of hydroxybenzene and aminobenzene isomers on platinum electrodes to assemble interference- free electrochemical biosensors, Electrochim. Acta 41 (1996) 1793-1800.
11. [11]
  [11] R.J. Geise, J.M. Adams, N.J. Barone, A.M. Yacynych, Electropolymerized films to prevent interferences and electrode fouling in biosensors, Biosens. Bioelectron. 6 (1991) 151-160.
12. [12]
  [12] E.J. Brisbois, H. Handa, T.C. Major, R.H. Bartlett, M.E. Meyerhoff, Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped elast-eon E2As polymer, Biomaterials 34 (2013) 6957-6966.
13. [13]
  [13] D. Cozzens, A. Luk, U. Ojha, M. Ruths, R. Faust, Surface characterization and protein interactions of segmented polyisobutylene-based thermoplastic polyurethanes, Langmuir 27 (2011) 14160-14168.
14. [14]
  [14] A. Simmons, A.D. Padsalgikar, L.M. Ferris, L.A. Poole-Warren, Biostability and biological performance of a PDMS-based polyurethane for controlled drug release, Biomaterials 29 (2008) 2987-2995.
1. [1]
  Erzhuo Cheng , Yunyi Li , Wei Yuan , Wei Gong , Yanjun Cai , Yuan Gu , Yong Jiang , Yu Chen , Jingxi Zhang , Guangquan Mo , Bin Yang . Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2024, 35(9): 109386-. doi: 10.1016/j.cclet.2023.109386
2. [2]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
3. [3]
  Chaozheng He , Jia Wang , Ling Fu , Wei Wei . Nitric oxide assists nitrogen reduction reaction on 2D MBene: A theoretical study. Chinese Chemical Letters, 2024, 35(5): 109037-. doi: 10.1016/j.cclet.2023.109037
4. [4]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
5. [5]
  Runze Liu , Yankai Bian , Weili Dai . Qualitative and quantitative analysis of Brønsted and Lewis acid sites in zeolites: A combined probe-assisted 1H MAS NMR and NH3-TPD investigation. Chinese Journal of Structural Chemistry, 2024, 43(4): 100250-100250. doi: 10.1016/j.cjsc.2024.100250
6. [6]
  Xueling Yu , Lixing Fu , Tong Wang , Zhixin Liu , Na Niu , Ligang Chen . Multivariate chemical analysis: From sensors to sensor arrays. Chinese Chemical Letters, 2024, 35(7): 109167-. doi: 10.1016/j.cclet.2023.109167
7. [7]
  Xiaoyan Peng , Xuanhao Wu , Fan Yang , Yefei Tian , Mingming Zhang , Hongye Yuan . Gas sensors based on metal-organic frameworks: challenges and opportunities. Chinese Journal of Structural Chemistry, 2024, 43(3): 100251-100251. doi: 10.1016/j.cjsc.2024.100251
8. [8]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
9. [9]
  Yi Zhu , Jingyan Zhang , Yuchao Zhang , Ying Chen , Guanghui An , Ren Liu . Designing unimolecular photoinitiator by installing NHPI esters along the TX backbone for acrylate photopolymerization and their applications in coatings and 3D printing. Chinese Chemical Letters, 2024, 35(7): 109573-. doi: 10.1016/j.cclet.2024.109573
10. [10]
  Yue Li , Minghao Fan , Conghui Wang , Yanxun Li , Xiang Yu , Jun Ding , Lei Yan , Lele Qiu , Yongcai Zhang , Longlu Wang . 3D layer-by-layer amorphous MoS_x assembled from [Mo₃S₁₃]^2- clusters for efficient removal of tetracycline: Synergy of adsorption and photo-assisted PMS activation. Chinese Chemical Letters, 2024, 35(9): 109764-. doi: 10.1016/j.cclet.2024.109764
11. [11]
  Min Chen , Boyu Peng , Xuyun Guo , Ye Zhu , Hanying Li . Polyethylene interfacial dielectric layer for organic semiconductor single crystal based field-effect transistors. Chinese Chemical Letters, 2024, 35(4): 109051-. doi: 10.1016/j.cclet.2023.109051
12. [12]
  Xinxiu Yan , Xizhe Huang , Yangyang Liu , Weishang Jia , Hualin Chen , Qi Yao , Tao Chen . Hyperbranched polyamidoamine protective layer with phosphate and carboxyl groups for dendrite-free Zn metal anodes. Chinese Chemical Letters, 2024, 35(10): 109426-. doi: 10.1016/j.cclet.2023.109426
13. [13]
  Yanrui Liu , Paramaguru Ganesan , Peng Gao . Harnessing d-f transition rare earth complexes for single layer white organic light emitting diodes. Chinese Journal of Structural Chemistry, 2024, 43(9): 100369-100369. doi: 10.1016/j.cjsc.2024.100369
14. [14]
  Wenyi Mei , Lijuan Xie , Xiaodong Zhang , Cunjian Shi , Fengzhi Wang , Qiqi Fu , Zhenjiang Zhao , Honglin Li , Yufang Xu , Zhuo Chen . Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells. Chinese Chemical Letters, 2024, 35(5): 108825-. doi: 10.1016/j.cclet.2023.108825
15. [15]
  Huipeng Zhao , Xiaoqiang Du . Polyoxometalates as the redox anolyte for efficient conversion of biomass to formic acid. Chinese Journal of Structural Chemistry, 2024, 43(2): 100246-100246. doi: 10.1016/j.cjsc.2024.100246
16. [16]
  Dan-Ying Xing , Xiao-Dan Zhao , Chuan-Shu He , Bo Lai . Kinetic study and DFT calculation on the tetracycline abatement by peracetic acid. Chinese Chemical Letters, 2024, 35(9): 109436-. doi: 10.1016/j.cclet.2023.109436
17. [17]
  Jing Wang , Zhongliao Wang , Jinfeng Zhang , Kai Dai . Single-layer crystalline triazine-based organic framework photocatalysts with different linking groups for H2O2 production. Chinese Journal of Structural Chemistry, 2023, 42(12): 100202-100202. doi: 10.1016/j.cjsc.2023.100202
18. [18]
  Shuo Zhang , Haitao Liao , Zhi-Qun Liu , Chong Yan , Jia-Qi Huang . Re-evaluating the nano-sized inorganic protective layer on Cu current collector for anode free lithium metal batteries. Chinese Chemical Letters, 2024, 35(7): 109284-. doi: 10.1016/j.cclet.2023.109284
19. [19]
  Xinyi Hu , Riguang Zhang , Zhao Jiang . Depositing the PtNi nanoparticles on niobium oxide to enhance the activity and CO-tolerance for alkaline methanol electrooxidation. Chinese Journal of Structural Chemistry, 2023, 42(11): 100157-100157. doi: 10.1016/j.cjsc.2023.100157
20. [20]
  Fei Jin , Bolin Yang , Xuanpu Wang , Teng Li , Noritatsu Tsubaki , Zhiliang Jin . Facilitating efficient photocatalytic hydrogen evolution via enhanced carrier migration at MOF-on-MOF S-scheme heterojunction interfaces through a graphdiyne (CnH2n-2) electron transport layer. Chinese Journal of Structural Chemistry, 2023, 42(12): 100198-100198. doi: 10.1016/j.cjsc.2023.100198

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(456)
HTML views(19)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142