Citation: Shuang-Hong Hao, Xue-Yan Zhang, Dao-Qing Dong, Zu-Li Wang. Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp³)H bond functionalization[J]. Chinese Chemical Letters, ;2015, 26(5): 599-602. doi: 10.1016/j.cclet.2014.12.018 shu

Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp³)H bond functionalization

1.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

Corresponding author: Zu-Li Wang,
Received Date: 8 January 2014
Available Online: 10 December 2014
Fund Project: Financial support from the National Natural Science Foundation of China (No. 21402103) (No. 21402103) the research fund of Qingdao Agricultural University’s High-level Person (No. 631303) (No. 631303)

A method of C(sp³)-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.
- Alumina-supported heteropoly acid,
- C(sp³)-H functionalization,
- Azaarenes,
- 3-Hydroxy-2-oxindoles,
- Isatin
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沈阳化工大学材料科学与工程学院沈阳 110142

Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp3)H bond functionalization

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通讯作者: 陈斌, bchen63@163.com

Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp³)H bond functionalization