Citation: Yan Wu, Wei-Qi Chen, Yu-Qing Zhao, Hu-Ri Piao. Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity[J]. Chinese Chemical Letters, ;2015, 26(3): 334-338. doi: 10.1016/j.cclet.2014.11.013 shu

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wu ^a ,
Wei-Qi Chen ^b ,
Yu-Qing Zhao ^c,, ,
Hu-Ri Piao ^a,,

1.
a Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, Yanji 133000, China;
2.
b Department of Chemistry, Fudan University, Shanghai 200433, China;
3.
c School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Corresponding author: Yu-Qing Zhao, Hu-Ri Piao,
Received Date: 1 August 2014
Available Online: 17 October 2014
Fund Project:

An efficient method has been developed for the synthesis of a series of (20R)-panaxadiol derivatives (4a-w) using a continuous-flow microreactor. The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines (i.e., PC-3 and LNCaP cells), and their cytotoxicities were evaluated using a standard MTT assay. Compounds 4c, 4h, 4p, 4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol, which was used as a reference standard.
- Flow chemistry,
- Microreactor,
- Panaxadiol,
- Anti-tumor activity
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