Citation: Dong Wang, William E. Crowe. A facile approach to tricyclo[6.4.0.0^4,9]-dodecane framework[J]. Chinese Chemical Letters, ;2015, 26(2): 238-242. doi: 10.1016/j.cclet.2014.11.003 shu

A facile approach to tricyclo[6.4.0.0^4,9]-dodecane framework

Dong Wang ^a,, ,
William E. Crowe ^b

a Longwood Biopharmaceuticals, Inc.
a Longwood Biopharmaceuticals, Inc.,Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China;
2.
b Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA

Corresponding author: Dong Wang,
Received Date: 17 August 2014
Available Online: 21 October 2014
Fund Project: We thank Frank Fronczek (LSU) for assistance with X-ray crystallography. Financial support from TianJin Municipal Science and Technology Commission (No. 11ZCKFSY06200) is greatly acknowledged. (LSU)

The unusual tricyclo[6.4.0.0^4,9]dodecane framework was constructed in eight linear steps in 13% overall yield. An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed. The key steps involve a Robinson annulation, a base induced decarboxylation and epimerization in a single step, and an intramolecular alkylation.
- Tricyclo[6.4.0.0^4,9]dodecane,
- Vinigrol,
- Robinson annulation,
- Bicyclo[3.3.1]nonane
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沈阳化工大学材料科学与工程学院沈阳 110142

A facile approach to tricyclo[6.4.0.04,9]-dodecane framework

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通讯作者: 陈斌, bchen63@163.com

A facile approach to tricyclo[6.4.0.0^4,9]-dodecane framework