Citation: Xiao-Hang Yang, Shu Li, Zhi-Shu Tang, Xi-Di Yu, Tin Huang, Yong Gao. A simple, water-soluble, Fe³⁺-selective fluorescent probe and its application in bioimaging[J]. Chinese Chemical Letters, ;2015, 26(1): 129-132. doi: 10.1016/j.cclet.2014.09.025 shu

A simple, water-soluble, Fe³⁺-selective fluorescent probe and its application in bioimaging

Xiao-Hang Yang ^a ,
Shu Li ^a ,
Zhi-Shu Tang ^a ,
Xi-Di Yu ^b ,
Tin Huang ^b ,
Yong Gao ^b,c,,

1.
a Medical Technology Department, Shaanxi College of Traditional Chinese Medicine, Xianyang 712046, China;
2.
b College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou 350007, China;
3.
c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

Corresponding author: Yong Gao,
Received Date: 17 July 2014
Available Online: 18 September 2014
Fund Project: This work was supported by Natural Science Foundationof Fujian Province (No. 2013H0019) (No. 2013H0019) the Science Foundation of Education Department of Fujian Province (No. JA11064) (No. JA11064) the Open Foundation of the State Key Laboratory of Fine Chemicals (No. KF1307) (No. KF1307)

A simple, water-soluble, Fe³⁺-selective fluorescent probe, derived from rhodamine B, was synthesized and characterized. The probe exhibits a fluorescence response toward Fe³⁺ with acceptable sensitivity and selectivity and even facilitates visual or naked-eye detection of Fe³⁺. The experiment results show that the response of the probe to Fe³⁺ is pH-independent over a wide range of 4.0-10.0. In addition, fluorescence microscopic imaging experiments have proven that the probe is cell permeable and can be used for monitoring intracellular Fe³⁺ in living cells.
- Fluorescent probe,
- Ferric ion,
- Aqueous solution,
- Fluorescent imaging
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A simple, water-soluble, Fe³⁺-selective fluorescent probe and its application in bioimaging