Citation: Zhi Wang, Chun-Yu Wang, Hao-Ran Wang, Hong Zhang, Ya-Lun Su, Teng-Fei Ji, Lei Wang. Lipase-catalyzed Knoevenagel condensation between α, β-unsaturated aldehydes and active methylene compounds[J]. Chinese Chemical Letters, ;2014, 25(05): 802-804. doi: 10.1016/j.cclet.2014.03.036 shu

Lipase-catalyzed Knoevenagel condensation between α, β-unsaturated aldehydes and active methylene compounds

Zhi Wang ^a ,
Chun-Yu Wang ^c ,
Hao-Ran Wang ^a ,
Hong Zhang ^a ,
Ya-Lun Su ^b ,
Teng-Fei Ji ^b,, ,
Lei Wang ^a,,

1.
a Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130023, China;
2.
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
3.
c State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130023, China

Corresponding author: Teng-Fei Ji, Lei Wang,
Received Date: 15 January 2014
Available Online: 11 March 2014
Fund Project:

A simple and efficient Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds is reported. Notably, this condensation can be catalyzed by PPL (lipase from porcine pancreas) with satisfied yields (49%-92%). Moreover, PPL induces moderate Z/E selectivity in the Knoevenagel condensation.
- Lipase,
- Knoevenagel condensation,
- α,β-Unsaturated aldehyde,
- Active methylene compound
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