Citation: Hong-Ping Long, Fu-Shuang Li, Kang-Ping Xu, Zhong-Bao Yang, Jing Li, Jun Peng, Gui-Shan Tan. Bioactive compounds from Selaginella involven Spring that protect PC-12 cells[J]. Chinese Chemical Letters, ;2014, 25(05): 805-808. doi: 10.1016/j.cclet.2014.03.024 shu

Bioactive compounds from Selaginella involven Spring that protect PC-12 cells

1.
a School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;
2.
b Xiangya Hospital of Central South University, Changsha 410008, China

Corresponding author: Gui-Shan Tan,
Received Date: 13 January 2014
Available Online: 4 March 2014
Fund Project: This research was supported by National Natural Science Foundation (No. 31370370) (No. 31370370) the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057) (No. 20100162110057)

Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8'S)-4,4',8-trihy-droxyl- 3,3'-dimethoxyl-9'-lignanolide (2) and a new natural product 4,4'-dihydroxyl-3,3',5,5'- dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2DNMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
- Selaginella,
- Selaginella involven Spring,
- Abietane diterpenoid,
- Lignans,
- PC-12 cell
1. [1]
  [1] M.X. Lu, K.L. Huang, S.Y. Shi, H. Zhang, Study on the chemical constituents of Selaginella invovens Spring and antibaceterial activity, Nat. Prod. Res. Dev. 21 (2009) 973-975.
2. [2]
  [2] K.L. Chen, G.W. Plumb, R.N. Bennett, Y. Bao, Antioxidant activities of extracts from five anti-viral medicinal plants, J. Ethnopharmacol. 96 (2005) 201-205.
3. [3]
  [3] C.J. Wang, C.P. Hu, K.P. Xu, et al., Protective effect of selaginellin on glutamateinduced cytotoxicity and apoptosis in differentiated PC₁₂ cells, N-S Arch. Pharmacol. 381 (2010) 73-81.
4. [4]
  [4] R.C. Swamy, O. Kunert, W. Schühly, et al., Structurally unique biflavonoids from Selaginella chrysocaulosand and Selaginella bryopteris, Chem. Biodivers. 3 (2006) 405-413.
5. [5]
  [5] S.H. Qi, S. Zhang, J.S. Huang, et al., Glycerol derivatives and sterols from Sargassum parvivesiculosum, Chem. Pharm. Bull. 52 (2004) 986-988.
6. [6]
  [6] J.F. Liu, K.P. Xu, D.J. Jiang, et al., A new flavonoid from Selaginella tamariscina, Chin. Chem. Lett. 20 (2009) 595-597.
7. [7]
  [7] X. Wang, Z.L. Li, L.L. Gao, J.N. Li, H.M. Hua, Chemical constituents of Selaginella tamariscina Spring, Shenyang Pharm. Univ. 126 (2009) 623-625.
8. [8]
  [8] C.F. Chyu, H.C. Lin, Y.H. Kuo, New abietane and seco-abietane diterpenes from the root of Taiwania cryptomerioides, Chem. Pharm. Bull. 53 (2005) 11-14.
9. [9]
  [9] W. Yuan, Z.M. Lu, Y. Liu, et al., Three new podocarpane-type diter penoids from Callus of Securinega, Chem. Pharm. Bull. 53 (2005) 1610-1612.
10. [10]
  [10] S.S. Liu, H.L. Zhang, S.W. Zhang, et al., Abietane diterpenoids from Clerodendrum bungei, J. Nat. Prod. 71 (2008) 755-759.
11. [11]
  [11] Y. Inaba, T. Hasuda, Y. Hitotsuyangagi, et al., Abietane diterpenoids and a sesquiterpene pyridine alkaloid from Euonymus lutchuensis, J. Nat. Prod. 76 (2013) 1085-1090.
12. [12]
  [12] F. Kawmura, S. Kawai, H. Ohashi, Sesquilignans and lignans from Tsuga heterophylla, Phytochemistry 44 (1997) 1351-1357.
13. [13]
  [13] L.M.X. Lopes, M. Yoshida, O.R. Gottlieb, Dibenzylbutyrolactone lignans from Virola sebifera, Phytochemistry 22 (1983) 1516-1518.
14. [14]
  [14] B.R. Prabhu, N.B. Mulchandani, Lignans from Piper cubeba, Phytochemistry 24 (1985) 329-331.
15. [15]
  [15] B.N. Su, W.P. Jones, M. Cuendet, et al., Constituents of the stems of macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1and-2, Phytochemistry 65 (2004) 2861-2866.
16. [16]
  [16] J.X. Zheng, Y. Zheng, H. Zhi, et al., New 3',8"-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia, Molecules 16 (2011) 6206- 6214.
17. [17]
  [17] C.T. Li, W.P. Zhang, S.H. Fang, et al., Baicalin attenuates oxygen-glucose deprivation induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells, Acta Pharm. Sin. 31 (2010) 137-144.
1. [1]
  . Cover and Table of Contents for Vol.40 No. 12. Acta Physico-Chimica Sinica, 2024, 40(12): -.
2. [2]
  Yunan Yuan , Zhimin Luo , Jie Chen , Chaoliang He , Kai Hao , Huayu Tian . Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting. Chinese Chemical Letters, 2024, 35(7): 109549-. doi: 10.1016/j.cclet.2024.109549
3. [3]
  Zizhuo Liang , Fuming Du , Ning Zhao , Xiangxin Guo . Revealing the reason for the unsuccessful fabrication of Li3Zr2Si2PO12 by solid state reaction. Chinese Journal of Structural Chemistry, 2023, 42(11): 100108-100108. doi: 10.1016/j.cjsc.2023.100108
4. [4]
  Ruizhi Yang , Xia Li , Weiping Guo , Zixuan Chen , Hongwei Ming , Zhong-Zhen Luo , Zhigang Zou . New thermoelectric semiconductors Pb5Sb12+xBi6-xSe32 with ultralow thermal conductivity. Chinese Journal of Structural Chemistry, 2024, 43(3): 100268-100268. doi: 10.1016/j.cjsc.2024.100268
5. [5]
  Ran Yu , Chen Hu , Ruili Guo , Ruonan Liu , Lixing Xia , Cenyu Yang , Jianglan Shui . 杂多酸H₃PW₁₂O₄₀高效催化MgH₂储氢. Acta Physico-Chimica Sinica, 2025, 41(1): 2308032-. doi: 10.3866/PKU.WHXB202308032
6. [6]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628
7. [7]
  Ya-Nan Yang , Zi-Sheng Li , Sourav Mondal , Lei Qiao , Cui-Cui Wang , Wen-Juan Tian , Zhong-Ming Sun , John E. McGrady . Metal-metal bonds in Zintl clusters: Synthesis, structure and bonding in [Fe₂Sn₄Bi₈]^3– and [Cr₂Sb₁₂]^3–. Chinese Chemical Letters, 2024, 35(8): 109048-. doi: 10.1016/j.cclet.2023.109048
8. [8]
  Jun-Jie Fang , Zheng Liu , Yun-Peng Xie , Xing Lu . Superatomic Ag₅₈ nanoclusters incorporating a [MS₄@Ag₁₂]²⁺ (M = Mo or W) kernel show aggregation-induced emission. Chinese Chemical Letters, 2024, 35(10): 109345-. doi: 10.1016/j.cclet.2023.109345
9. [9]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
10. [10]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
11. [11]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
12. [12]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
13. [13]
  Yanjing Li , Jiayin Li , Yuqi Chang , Yunfeng Lin , Lei Sui . Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell. Chinese Chemical Letters, 2024, 35(9): 109414-. doi: 10.1016/j.cclet.2023.109414
14. [14]
  Zhixue Liu , Haiqi Chen , Lijuan Guo , Xinyao Sun , Zhi-Yuan Zhang , Junyi Chen , Ming Dong , Chunju Li . Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging. Chinese Chemical Letters, 2024, 35(9): 109666-. doi: 10.1016/j.cclet.2024.109666
15. [15]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
16. [16]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
17. [17]
  Zheyi Li , Xiaoyang Liang , Zitong Qiu , Zimeng Liu , Siyu Wang , Yue Zhou , Nan Li . Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel. Chinese Chemical Letters, 2024, 35(11): 109592-. doi: 10.1016/j.cclet.2024.109592
18. [18]
  Qian Ren , Xue Dai , Ran Cen , Yang Luo , Mingyang Li , Ziyun Zhang , Qinghong Bai , Zhu Tao , Xin Xiao . A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution. Chinese Chemical Letters, 2024, 35(12): 110022-. doi: 10.1016/j.cclet.2024.110022
19. [19]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
20. [20]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(622)
HTML views(24)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142