Citation: Satish Gaddam, Harshavardhan Reddy Kasireddy, Karnakar Konkala, Ramesh Katla, Nageswar Yadavalli Venkata Durga. Synthesis of N-substituted-2-aminobenzothiazoles using nano copper oxide as a recyclable catalyst under ligand-free conditions, in reusable PEG-400 medium[J]. Chinese Chemical Letters, ;2014, 25(05): 732-736. doi: 10.1016/j.cclet.2014.02.003 shu

Synthesis of N-substituted-2-aminobenzothiazoles using nano copper oxide as a recyclable catalyst under ligand-free conditions, in reusable PEG-400 medium

1.
CSIR-Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500007, India

Corresponding author: Nageswar Yadavalli Venkata Durga,
Received Date: 11 July 2013
Available Online: 21 February 2014

A simple and practical method for the synthesis of N-substituted-2-aminobenzothiazoles via a crosscoupling reaction of 2-iodo anilines with isothiocyanates is envisaged using nano copper oxide as a recyclable catalyst and Cs₂CO₃ as a base in PEG-400, as a bio-degradable, reusable, inexpensive and nontoxic reaction medium, under ligand-free conditions. The present tandem process underlines environmental acceptability to access a wide range of N-substituted-2-aminobenzothiazoles in good to excellent yields.
- 2-Aminobenzothiazoles,
- 2-Iodoanilines,
- Isothiocyanates,
- CuO nanoparticles,
- Recyclability,
- PEG-400
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