Citation: Nan Zhao, Yao Ma, Gang Liu. Solution-phase synthesis of a muramyl dipeptide analogue MDA[J]. Chinese Chemical Letters, ;2011, 22(12): 1443-1446. doi: 10.1016/j.cclet.2011.07.020 shu

Solution-phase synthesis of a muramyl dipeptide analogue MDA

Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 25 May 2011

Fund Project: This research is supported financially by the National Natural Science Foundation of China (No.90713045).

The solution-phase synthesis of a muramyl dipeptide (MDP) analogue of N^α-[4-chlorocinnamoyl-L-alanyl-D-isoglutaminyl]-L-lysine (MDA, 2) is reported that possesses the features of easy feasibility, safety and low cost in large scale of synthesis.
- Muramyl dipeptide analogue,
- Solution-phase synthesis,
- MDA
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