Citation: Paresh N. Patel, Khyati D. Patel, Hasmukh S. Patel. Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes[J]. Chinese Chemical Letters, ;2011, 22(11): 1297-1230. doi: 10.1016/j.cclet.2011.05.042 shu

Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat 388120, India

Received Date: 29 March 2011

A novel 5-((4-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol (HTPSMQol) was synthesized by optimized reaction of 4-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-ylsulfonyl)aniline with 5-chloromethyI-8-hydroxy_quinoline hydrochloride (CMHQ). Also complexes of HTPSMQol were prepared by using various M (Ⅱ) metal salts. All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms. The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin.
- 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine (THTPs),
- 8-Hydroxyquinoline (8HQs),
- Sulfonamide,
- Antimicrobial activity
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