Secondary metabolites from fungus Alternaria sp.CIB 108

A new compound, 3-butyryl-6-[rel-(1S, 2S)-1, 2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one (1), was isolated from the solid fermented rice culture of Alternaria sp. CIB 108, along with three known ones, deoxyradicinin (2), 3-epiradicinol (3), and 3-epideoxyradicinol (4). Their structures were elucidated on the basis of spectroscopic data. The single crystal X-ray diffraction was applied to further clarify the structure of 1. Furthermore, compounds 1-4 possessed no cytotoxicity against several cell lines (HeLa, HepG2, and Ros) and showed no antibacterial activity at 40 μmol/L.