Citation: A. Kuraitheerthakumaran, S. Pazhamalai, M. Gopalakrishnan. An efficient and solvent-free one-pot synthesis of 1,4-dihydropyridines under microwave irradiation[J]. Chinese Chemical Letters, ;2011, 22(10): 1199-1202. doi: 10.1016/j.cclet.2011.05.003 shu

An efficient and solvent-free one-pot synthesis of 1,4-dihydropyridines under microwave irradiation

Department of Chemistry, Annamalai University, Annamalainagar 608002, India

Received Date: 21 February 2011

Fund Project: We wish to thank Annamalai University for supporting this work.

An efficient synthesis of 1, 4-dihydropyridines using lanthanum oxide as a catalyst from aldehydes, β-ketoester and ammonium acetate without solvent under the irradiation of microwave is described. Compared with the classical Hantzsch reaction, this new method has the advantage of good yield (90-98%) and short reaction time (40-80 s).
- Hantzsch reaction,
- 1,4-Dihydropyridine,
- Microwave,
- Solvent free,
- Lanthanum oxide
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