Citation: Hai Bin Lin, Qing Xiang Wang, Cong Min Zhang, Wen Qi Li. Crystal structure and DNA binding studies of a cobalt(Ⅱ) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid[J]. Chinese Chemical Letters, ;2011, 22(8): 969-972. doi: 10.1016/j.cclet.2011.03.003 shu

Crystal structure and DNA binding studies of a cobalt(Ⅱ) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid

a Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou 363000, China;
b Department of Bioscience with Technique, Zhangzhou Normal University, Zhangzhou 363000, China

Received Date: 25 October 2010

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20805041), Training Programme Foundation for Excellent Youth Researching Talents of Fujian's Universities (No. JA10201), Key Provincial University Project of Fujian (No. 2008F5064) and Research Foundation of Fujian Education Department (No. JA09170).

A cobalt(Ⅱ) complex containing mixed-ligands of 1, 10-phenathrolinc (phen) and glycollic acid (GA). [Co(GA)₂(phen)] was synthesized and its structure was characterized by X-ray diffraction. The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods. Electronic absorption spectrum experiments showed that after interaction with DNA, the characteristic absorption peaks of [Co(GA)₂(phen)] underwent hypochromic effect as well as red-shift. Also, the binding strength of 3.8×l0⁴ L/mol was estimated by titration method. Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA. All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.
- Cobalt complex,
- DNA binding,
- Electronic absorption spectra,
- Electrochemistry
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