Citation: Bo Han, Wei Huang, Zhen Rui Xu, Xiao Ping Dong. Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst[J]. Chinese Chemical Letters, ;2011, 22(8): 923-926. doi: 10.1016/j.cclet.2011.01.038 shu

Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst

a State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;
b State Key Laboratory of Oral Diseases, Department of Orthodontics, West China College of Stomatolgy, Sichuan University, Chengdu 610041, China

Received Date: 9 November 2010

Fund Project: We thank the Scientific Research Fund of Sichuan Provincial Education Department (No. 310-347) and Technology Department of Chengdu University of TCM (Nos. 310-446 and 310-448) for financial support.

The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thiourea-guanidine bifunctional organocatalyst. The novel transformations exhibited high diastereoselectivities, and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities (up to 88% ee).
- Aza-Henry reaction,
- Thiourea,
- Guanidine,
- Nitroacetate,
- Organocatalysis
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