Citation: Jing Bo Shi, Song Xu, Ya Ping Wang, Jing Jing Li, Qi Zheng Yao. Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity[J]. Chinese Chemical Letters, ;2011, 22(8): 899-902. doi: 10.1016/j.cclet.2011.01.010 shu

Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity

a School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b School of Pharmacy, Anhui Medical University, Hefei 230032, China;
c Anhui Zhaoke Pharmaceutical Co., Ltd., Hefei 230088, China

Received Date: 3 November 2010

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 30572240).

New pyrimidine nucleoside derivatives with nitric oxide (NO) donor were systematically synthesized. The antivirus activities of these nucleoside analogues against vesicular stomatitis virus (VSV) in Wish cell were evaluated. It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir, while their toxicities were similar or lower to acyclovir.
- Pyrimidine nucleoside,
- NO-donor,
- Antivirus,
- Furoxans,
- Oximes,
- Synthesis
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