Citation: Ning Zhang, Yi Su, Miao Yu. A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain[J]. Chinese Chemical Letters, ;2011, 22(7): 863-866. doi: 10.1016/j.cclet.2011.01.006 shu

A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain

Ning Zhang ^a, ,
Yi Su ^a ,
Miao Yu ^a,b

a Department of Chemistry and Chemical Engineering, Huanghuai University, Zhumadian 463000, China;
b Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China

Received Date: 26 October 2010

Fund Project: We thank the National Science Foundation of China (NSFC) (No.20973072) for financial support.

A novel cell-impermeable zinc sensor was synthesized by incorporating poly(ethylene glycol) (PEG) to N-(8-quinolyl)-p-aminobenzenesulfonamide (HQAS) group. The polymeric zinc sensor combines both valuable features of HQAS and PEG. The HQAS of the sensor has the similar functions to TSQ, and exhibits a good fluorescence response to Zn²⁺ but poor fluorescence responses to other metal ions. The PEG chain can prevent the sensor to permeate healthy cell membrane. The stained experiments with the yeast cells as model showed that the sensor cannot stain the healthy yeast cells, but only the damaged or died yeast cells. These results indicated the novel zinc probe was a typical cell-impermeable zinc sensor.
- Zinc ion,
- Sensor,
- Yeast,
- Poly(ethylene glycol),
- Fluorescence
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