Citation: Yan Ming Liu, Long Fei Peng, Lin Mei, Li Juan Liu. Determination of diastereoisomeric alkaloids in urine by capillary electrophoresis with electrochemiluminescence detection[J]. Chinese Chemical Letters, ;2011, 22(2): 197-200. doi: 10.1016/j.cclet.2010.10.019 shu

Determination of diastereoisomeric alkaloids in urine by capillary electrophoresis with electrochemiluminescence detection

College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, China

Received Date: 1 June 2010

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21075106), Henan Innovation Project for University Research Talents (No. 2005126) and Natural Science Foundation of Henan Province of China (No. 092300410122).

A new and simple capillary electrophoresis with electrochemiluminescence detection was developed for the separation and the quantification of a pair of diastereoisomeric alkaloids (ephedrine and pseudoephedrine). The limits of detection (S/N=3) were 4.5×10^-8 mol/L for ephedrine and 5.2×10^-8 mol/L for pseudoephedrine, respectively. The RSDs of migration time and peak area were less than 1.3 and 2.5% (n=5), respectively. The applicability of the propose method was illustrated in the determination of ephedrine and pseudoephedrine in human urine, ephedrine in nasal drops, and the monitoring of pharmacokinetics for pseudoephedrine.
- CE,
- Electrochemiluminescence,
- Alkaloids,
- Urine analysis,
- Pharmacokinetics
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