Citation: Shankaraiah G. Konda, Baseer M. Shaikh, Sanjay A. Chavan, Bhaskar S. Dawane. Polyethylene glycol(PEG-400):An efficient and recyclable reaction medium for the synthesis of novel 1;5-benzodiazepines and their antimicrobial activity[J]. Chinese Chemical Letters, ;2011, 22(1): 65-68. doi: 10.1016/j.cclet.2010.09.012 shu

Polyethylene glycol(PEG-400):An efficient and recyclable reaction medium for the synthesis of novel 1;5-benzodiazepines and their antimicrobial activity

Organic Research Laboratory, Department of Chemistry Yeshwant Mahavidyalaya, Nanded-431602(M.S)India

Received Date: 20 May 2010

Fund Project: BSD gratefully acknowledge to UGC-New Delhi,for Post Doctoral research award and SGK is also thankful UGC-New Delhi for D. S. Kothari Post Doctoral fellowship. The authors are grateful to the Director,IICT,Hyderabad for providing necessary instrumental facilities.

A new series of imidazole-containing 1, 5-benzodiazepines have been synthesized by the condensation of chalcones with ophenylenediamine using piperidine in polyethylene glycol(PEG-400)as an efficient and green reaction solvent.The advantages of this protocol are environmental friendliness, easy work-up, high yields, mild reaction condition and avoidance of expensive catalyst.Furthermore, newly synthesized compounds were evaluated for their antimicrobial activity.
- PEG-400,
- Chalcones,
- o-Phenylenediamine,
- 1;5-Benzodiazepines,
- Antimicrobial activity
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