Citation: Yong Qiang Li, Yu Liang Zhang, Sheng Quan Hu, Yu Ling Wang, Hong Rui Song, Zhi Qiang Feng, Lei Lei, Quan Liu, Zhu Fang Shen. Design,synthesis and biological evaluation of novel glucokinase activators[J]. Chinese Chemical Letters, ;2011, 22(1): 73-76. doi: 10.1016/j.cclet.2010.07.023 shu

Design,synthesis and biological evaluation of novel glucokinase activators

a Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;
b School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 26 May 2010

Fund Project: This project was financially supported by the National Nature Science Foundation of China (No.30572256).

A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay.The structure-activity relationship (SAR) is discussed.The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.
- Diabetes,
- Glucokinase activators,
- Benzamide derivatives
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