Citation: Jun Chao Shao, Zhi Hua Ye, Hai Xia Lin, Dian Long Wang, Na Han. Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin Ⅵ[J]. Chinese Chemical Letters, ;2010, 21(11): 1273-1276. doi: 10.1016/j.cclet.2010.07.001 shu

Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin Ⅵ

Department of Chemistry, Shanghai University, Shanghai 200444, China

Received Date: 15 January 2010

Fund Project: The authors are grateful to the National Natural Science Foundation of China (No.30672506) and Leading Academic Discipline Project of Shanghai Municipal Education Commission (No.J50102).

New D-seco-taxoids were synthesized from 1-deoxybaccatin Ⅵ and their structures were confirmed by ¹H NMR, ¹³C NMR, ESIMS and X-ray crystallography. The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance (MDR) reversal agents and new synthetic precursors of paclitaxel analogues.
- Taxoids,
- 1-Deoxybaecatin Ⅵ,
- Oxetane ring,
- Paclitaxel
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