Citation: Jin Hui Yang, Yu Heng Zhang, Hong Jun Li, Shi Zhi Jiang, Yun Feng Li. First total synthesis of (±)-puyanin and (±)-4'-O-methylbonannione[J]. Chinese Chemical Letters, ;2010, 21(11): 1267-1269. doi: 10.1016/j.cclet.2010.06.037 shu

First total synthesis of (±)-puyanin and (±)-4'-O-methylbonannione

Key Laboratory of Energy Sources and Chemical Engineering of Ningxia, Ningxia University, Yinchuan 750021, China

Received Date: 16 April 2010

Fund Project: This work was financially supported by the National Natural Science Foundation (Nos.20562010, 20962016), Ningxia Natural Science Foundation, Program for New Century Excellent Talents in University (No.NCET-09-0860) and the National Basic Research Program 973 of China (No.2010CB534916).

A facile approach for the first total synthesis of two naturally occurring geranylated flavonoids, (±)-puyanin 1 and (±)-4'-O-methylbonannione 2 has been obtained with total yield 27% and 21%, respectively. The key steps were regioseleetive cyclization of geranylated trihydroxychalcone and regioselective geranylation of 2, 4, 6-trihydroxyacetophenone.
- Puyanin,
- 4'-O-Methylbonannione,
- Flavanone,
- Geranylated flavonoids,
- Total synthesis
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