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Citation: Rui Sheng Xiong, Qing Jie Zhao, Hang Hang Zhu, Zheng Liu, Ya Bing Wei, Jing Shan Shen. Synthesis of novel analogues of zanamivir as neuraminidase inhibitors[J]. Chinese Chemical Letters, ;2010, 21(11): 1338-1341. doi: 10.1016/j.cclet.2010.06.021 shu

Synthesis of novel analogues of zanamivir as neuraminidase inhibitors

a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
b College of Materials Science and Engineering, Nanjing University of Technology, Nanjing 210009, China;
c Topharman Shanghai Co., Ltd., Shanghai 201209, China

Received Date: 23 March 2010

Fund Project: This work was supported by National Great Project of Scientific and Technical Supporting Programs Funded by Ministry of Science&Technology of China (No.2006BAI01B02).

A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was described. The formation of amides from the acid with corresponding amines, followed by click chemistry generated the triazole substituted compounds as novel analogues of neuraminidase inhibitors in good yields.
- Zanamivir,
- Triazole,
- Click chemistry
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