Citation: Xin Guo, Yi Liang Li, Yu Fei Liu, Hui Yuan Guo, Yu Cheng Wang. Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl) quinolone derivatives[J]. Chinese Chemical Letters, ;2010, 21(10): 1141-1144. doi: 10.1016/j.cclet.2010.06.011 shu

Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl) quinolone derivatives

Xin Guo ^a,b, ,
Yi Liang Li ^a,c ,
Yu Fei Liu ^b ,
Hui Yuan Guo ^a ,
Yu Cheng Wang ^a

a Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
b College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;
c Tianjin Institute of Pharmaceutical Research, Tianjin Key Laboratory of Molecular Design & Drug Discovery, Tianjin 300193, China;
d Xuzhou Medical College, Xuzhou 221004, China

Received Date: 25 February 2010

Fund Project: This work was supported by the National Major Science and Technology Project of China ("Innovation and Development of New Drugs",No.2009ZX09301-003).

A series of novel 7-(3-aminopyrrolo[3, 4-c]pyrazol-5(2H, 4H, 6H)-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 6g, 7g and 7h with the potencies similar to those of gemifloxacin, moxifloxacin, gatifloxacin and levofloxacin against Gram-positive organisms, worth further investigation.
- Fluoroquinolone,
- Synthesis,
- Antibacterial activities
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