Citation: Tian Cai Wang, Ju Zhi Wei, Chuan Sheng Guo, Hui Bin Zhang, Hou Xing Fan. Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives[J]. Chinese Chemical Letters, ;2010, 21(12): 1407-1410. doi: 10.1016/j.cclet.2010.05.026 shu

Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives

a Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b Shanghai Sun-sail Pharmaceutical Science & Technology Co., Ltd., Shanghai 201203, China

Received Date: 15 April 2010

A series of novel derivatives of indirubin were synthesized and evaluated for their anti-proliferative activity against human cancer cell lines of SGC7901, A549, HL-60, SK-BR-3 and HCT116. Most of the compounds displayed more potent activity than Sunitinib. In addition, the derivatives showed improved water solubility, which may be favorable to their pharmacokinetic performances.
- Anti-proliferative activity,
- Indirubin,
- Sunitinib
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