Citation: Dong Chen, Xin Zhai, Qiu Hui Yuan, Jian Luo, Si Chang Xie, Ping Gong. Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives[J]. Chinese Chemical Letters, ;2010, 21(11): 1326-1326. doi: 10.1016/j.cclet.2010.05.011 shu

Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives

Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 23 March 2010

A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and eytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC₅₀ values less than 100 μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg.
- 1H-benzimidazol-5-ol,
- Synthesis,
- Anti-HBV activity
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