Citation: Xiao Ming Zha, Fei Ran Zhang, Jia Qi Shan, Yi Hua Zhang, Jun O. Liu, Hong Bin Sun. Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives[J]. Chinese Chemical Letters, ;2010, 21(9): 1087-1090. doi: 10.1016/j.cclet.2010.04.020 shu

Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

a Center for Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China;
c Department of Pharmacology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Received Date: 23 February 2010

Fund Project: We thank Dr Sensen Lin (Jiangsu Center for Drug Screening,China Pharmaceutical University) for discussion about the biological aspects of this manuscript.

Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC₅₀=3.91 μmol/L).
- Solasodine,
- Derivatives,
- In vitro anticancer
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