Citation: Gan Jun Yuan, Kui Hong, Hai Peng Lin, Jia Li. Azalomycin F_4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp.211726[J]. Chinese Chemical Letters, ;2010, 21(8): 947-950. doi: 10.1016/j.cclet.2010.03.025 shu

Azalomycin F_4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp.211726

Gan Jun Yuan ^a,b, ,
Kui Hong ^a ,
Hai Peng Lin ^a ,
Jia Li ^c

a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;
b Department of Pharmacy, Hainan Medical College, Haikou 571101, China;
c National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Received Date: 7 December 2009

Fund Project: This research was financially supported by The National High Technology Development Project (863) (No. 2007AA09Z415) and The National Natural Science Foundation of China (No. U0633008).

Azalomycin F_4a 2-ethylpentyl ester,a new 36-membered macrocyclic lactone antibiotic,was isolated from mangrove actinomycete Streptomyces sp.211726.Its structure was elucidated on the basis of spectroscopic data.The compound showed broad-spectrum antifungal activity and moderate cytotoxicity against human colon tumor cell HCT-116.
- Streptomyces sp.211726,
- Azalomycin F_4a 2-ethylpontyl ester,
- Antifungal activity,
- Cytotoxity
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