Citation: Shu Lan Zhang, Xin Zhai, Shi Jiao Zhang, Hong Hao Yu, Ping Gong. Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives[J]. Chinese Chemical Letters, ;2010, 21(8): 939-942. doi: 10.1016/j.cclet.2010.03.016 shu

Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives

Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 25 December 2009

A series of quinoline-3-carbonitrile derivatives were designed and synthesized.Their cytotoxicity in vitro against four cancer cell lines (A549,HT-29,MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay.The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line.Among them,compounds 7c,7e,11b,11f and 11g were more active than Gefitinb against SMMC-7721 cell line.
- Quinoline-3-carbonitrile,
- Synthesis,
- Cytotoxicity
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