Citation: Dan Dan Zhai, Hui Zi Jin, Jian Jiang Zhong. A new sesquiterpene from hairy root culture of Artemisia annua[J]. Chinese Chemical Letters, ;2010, 21(5): 590-592. doi: 10.1016/j.cclet.2010.01.034 shu

A new sesquiterpene from hairy root culture of Artemisia annua

a State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China;
b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
c Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China

Received Date: 25 August 2009

Fund Project: Financial support from the Shanghai Leading Academic Discipline Project (No. B203 and B505) is gratefully acknowledged. Dr. Kanyaratt Supaibulwatana of Department of Biotechnology, Mahidol University, Thailand, kindly provided us with the hairy root culture. We also thank Prof. Weimin Zhao in the Shanghai Institute of Materia Medica for his help with the structure analysis.

A new sesquiterpene (Z)-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene (AMDT) was isolated and identified from the methanol extract of the hairy root culture of Artemisia annua. The structure of AMDT was determined based on the analysis of spectroscopic data, notably of the 2D NMR spectra. This new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC₅₀ values of 27.08 and 20.12 μmol/L, respectively.
- Artemisia annua,
- Sesquiterpene,
- Cytotoxicity
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