Citation: Hai Shan Jin, Li Ming Zhao. A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin[J]. Chinese Chemical Letters, ;2010, 21(5): 568-571. doi: 10.1016/j.cclet.2010.01.013 shu

A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin

School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, China

Received Date: 17 November 2009

Fund Project: This work was supported by Natural Science Foundation of Xuzhou Normal University (No. 08XLB08), Science and Technology Project of Xuzhou (No. XJ09078) and Universities Natural Science Foundation of Jiangsu Province (No. 09KJD150006).

Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction. The influence of the amount of solvent, base and formaldehyde toward the hydroxymethylation was discussed. The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product, while the thick reaction solution benefited the generation of the methylated quinizarins.
- Marschalk reaction,
- Hydroxymethylation,
- Emodin,
- Antitumor activity
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