Citation: Li Qin He, Jing Liu, Deng Ke Yin, Yi Hua Zhang, Xiao Shan Wang. Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents[J]. Chinese Chemical Letters, ;2010, 21(4): 381-384. doi: 10.1016/j.cclet.2009.11.033 shu

Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents

a Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;
b Anhui University of Traditional Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material Medical, Anhui, Hefei 230031, China

Received Date: 31 August 2009

A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f)were synthesized.The biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells(HepG2) in vitro.
- Matrine,
- Furoxan,
- Anti-minor activity,
- HepG
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