Citation: Xue Cui Shen, Bo Jiao, Shu Tao Ma. Synthesis and antibacterial activity of 4"-O-carbamoyl analogs of clarithromycin[J]. Chinese Chemical Letters, ;2010, 21(3): 257-260. doi: 10.1016/j.cclet.2009.11.023 shu

Synthesis and antibacterial activity of 4"-O-carbamoyl analogs of clarithromycin

School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

Received Date: 26 August 2009

Fund Project: This research was supported by Major R&D Program of New Drugs—National S&T Key Special Subject of China (No. 2009ZX09103-115), National Natural Science Foundation of China (No. 20872081) and Natural Science Foundation of Shandong (No. Y2006C31).

A series of novel 4"-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-snsceptible S. pneumoniae, Particularly, 4-fluorobenzyl carbamate 7a demonstrated potent activity against erythromycin-resistant S. pneumoniae encoded by the mef gene, and remarkably improved activity against erythromycin-resistant S. pneumoniae encoded by the erm gene, and the erm and mef genes.
- Clarithromycin analogs,
- O-carbamate')"> 4"-O-carbamate,
- Synthesis,
- Antibacterial activity,
- Resistant bacteria
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