Citation: Ying Jun Li, Li Jun Liu, Kun Jin, Yong Ting Xu, Su Qin Sun. Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles[J]. Chinese Chemical Letters, ;2010, 21(3): 293-296. doi: 10.1016/j.cclet.2009.11.008 shu

Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China;
b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China

Received Date: 10 July 2009

Fund Project: We thank the National Center for Drug Screening for determining bioactivity. This research was supported by the Education Office of Liaoning Province (No. 2008345).

A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5-[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1). Some of the tested compounds showed significant inhibitory activity.
- Triazolo-thiadiazoles,
- Synthesis,
- Bioactivity
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