Citation: Yi Kai Zhang, Zhi Liang Lv, Chun Juan Niu, Ke Li. Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives[J]. Chinese Chemical Letters, ;2010, 21(3): 290-292. doi: 10.1016/j.cclet.2009.10.010 shu

Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 6 July 2009

Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions. The structures of these novelly synthesized compounds were verified by ¹H NMR, ESI-MS and single crystal X-ray diffraction. Furthermore, all four compounds (most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG22.2.15 cell, making them promising drug candidates for potential bioactive molecule against hepatitis B.
- Substituted pyridin-2(1H)-one,
- Synthesis,
- Crystal structure,
- Anti-HBV activity
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