Citation: Lei Yuan, Jin Hui Wang, Tie Min Sun. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine[J]. Chinese Chemical Letters, ;2010, 21(2): 155-158. doi: 10.1016/j.cclet.2009.10.004 shu

Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 15 June 2009

All stereoisomers of asperphenamate la and patriscabratine 2a were achieved with a high yield,and total synthesis of 2a is firstly described here.The absolute configuration of patriscabratine was determined as(S,S).The compounds 1a-d and 2a-d have been tested by MTT assay in T47D,MDA-MB231,HL60,Hela and SGC-7901 cell lines in vitro.Among them,the(R,S)stereoisomer shows the strongest anticancer effects,while the(S,R)shows the weakest one.
- N,N'-substituted phenylalanine-phenylalaninol ester,
- Asperphenamate,
- Patfiscabratine,
- Total synthesis,
- Anticancer activity
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