Citation: Yong Mei Xiao, Pu Mao, Zhen Zhao, Liang Ru Yang, Xian Fu Lin. Regioselective enzymatic acylation of troxerutin in nonaqueous medium[J]. Chinese Chemical Letters, ;2010, 21(1): 59-62. doi: 10.1016/j.cclet.2009.08.017 shu

Regioselective enzymatic acylation of troxerutin in nonaqueous medium

a College of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China;
b Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Received Date: 8 July 2008

Fund Project: No. 82102330014), China, for financially supported to this work.We thank the Science and Technology hall of Henan Province (No. 072300420070

A series of monosubstituted troxerutin esters have been synthesized by enzyme-catalyzed regioselective acylation of troxerutin in nonaqueous medium. Using divinyl dicarboxylates (CH₂=CH-OOC-(CH₂)_n-COO-CH=CH₂, n=2, 3, 4, 7, 8, 11) featuring different chain length as acyl donors and alkaline protease from Bacillus subtilis as catalyst, troxerutin was regioselective acylated at B' ethoxyl group. The results indicated that the regioselectivity of the enzyme-catalyzed acylation was not affected by the chain length of the acyl donor.
- Troxerutin,
- Acylation,
- Enzymatic synthesis,
- Regioselectivity
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