Login In
Citation:
Ying Zhao, Ling Mei Sun, Xiao Ning Wang, Tao Shen, Mei Ji, Xia Li, Hong Xiang Lou. Microbial transformation of diosgenin by Syncephalastrum racemosum (Cohn) Schroeter[J]. Chinese Chemical Letters,
;2010, 21(1): 76-80.
doi:
10.1016/j.cclet.2009.08.015
-
Microbial transformation of diosgenin (1) by Syncephalastrum racemosum yielded five new polar metabolites, which were identified as (25R)-spirost-5-en-3β,7α,9α-triol-12-one (2), (25R)-spirost-5-en-3β,9α,12α-triol-7-one (3), (25R)-spirost-5-en-3β,9α-diol-7,12-dione(4), (25R)-spirost-4-en-9α,12β,14α-triol-3-one(5), and (25S)-spirost-4-en-9α,14α,25β-triol-3-one (6). Compounds 1-6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2, 3, and 6 were more potent than the parent compound 1.
-
Keywords:
- Biotransformation,
- Diosgenin,
- Syncephalastrum racemosum,
- Cytotoxicity
-
-
-
-
[1]
Ke Wu , Xiuqin Ruan , Shuolei Jia , Enyuan Wang , Qingfa Zhou . DABCO-catalyzed [3+4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives. Chinese Chemical Letters, 2025, 36(7): 110646-. doi: 10.1016/j.cclet.2024.110646
-
[2]
Jin Wang , Xiaoyan Pan , Junyu Zhang , Qingqing Zhang , Yanchen Li , Weiwei Guo , Jie Zhang . Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy. Chinese Chemical Letters, 2024, 35(8): 109187-. doi: 10.1016/j.cclet.2023.109187
-
[3]
Chuan Li , Yangyang Han , Yanan Zhai , Ke Li , Xingzhong Liu , Zhuan Zhang , Cai Jia , Yongsheng Che . Phomaketals A and B, pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.. Chinese Chemical Letters, 2024, 35(7): 109019-. doi: 10.1016/j.cclet.2023.109019
-
[4]
Yongjian Liu , Cen Liu , Haitao Guo , Jinchai Qi , Heng Chen , Yuping Yang , Tao Ma , Yonggang Liu . Alkaloids peganumiums A–C from Peganum harmala L., with two novel long conjugated structures. Chinese Chemical Letters, 2025, 36(8): 110558-. doi: 10.1016/j.cclet.2024.110558
-
[5]
Jing JIN , Zhuming GUO , Zhiyin XIAO , Xiujuan JIANG , Yi HE , Xiaoming LIU . Tuning the stability and cytotoxicity of fac-[Fe(CO)3I3]- anion by its counter ions: From aminiums to inorganic cations. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 991-1004. doi: 10.11862/CJIC.20230458
-
[1]
Metrics
- PDF Downloads(2)
- Abstract views(1308)
- HTML views(47)
DownLoad: