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Citation:
Ying Zhao, Ling Mei Sun, Xiao Ning Wang, Tao Shen, Mei Ji, Xia Li, Hong Xiang Lou. Microbial transformation of diosgenin by Syncephalastrum racemosum (Cohn) Schroeter[J]. Chinese Chemical Letters,
;2010, 21(1): 76-80.
doi:
10.1016/j.cclet.2009.08.015
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Microbial transformation of diosgenin (1) by Syncephalastrum racemosum yielded five new polar metabolites, which were identified as (25R)-spirost-5-en-3β,7α,9α-triol-12-one (2), (25R)-spirost-5-en-3β,9α,12α-triol-7-one (3), (25R)-spirost-5-en-3β,9α-diol-7,12-dione(4), (25R)-spirost-4-en-9α,12β,14α-triol-3-one(5), and (25S)-spirost-4-en-9α,14α,25β-triol-3-one (6). Compounds 1-6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2, 3, and 6 were more potent than the parent compound 1.
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Keywords:
- Biotransformation,
- Diosgenin,
- Syncephalastrum racemosum,
- Cytotoxicity
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