Citation: Yi Zheng, You Guang Sun, Yuan Zhang, Jing Jing Lv, Wen Chao Bi, Yuan Wei Ma, Hong Chen. Synthesis and cytotoxicity of novel podophyllotoxin derivatives[J]. Chinese Chemical Letters, ;2009, 20(12): 1431-1434. doi: 10.1016/j.cclet.2009.07.022
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In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents.Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3-yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro, KB and KBV using MTT methods in vitro.
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