Citation: Yi Zheng, You Guang Sun, Yuan Zhang, Jing Jing Lv, Wen Chao Bi, Yuan Wei Ma, Hong Chen. Synthesis and cytotoxicity of novel podophyllotoxin derivatives[J]. Chinese Chemical Letters, ;2009, 20(12): 1431-1434. doi: 10.1016/j.cclet.2009.07.022 shu

Synthesis and cytotoxicity of novel podophyllotoxin derivatives

Yi Zheng ^a,b,c, ,
You Guang Sun ^a ,
Yuan Zhang ^b,c ,
Jing Jing Lv ^b,c ,
Wen Chao Bi ^b,c ,
Yuan Wei Ma ^b,c ,
Hong Chen ^b,c

a School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300191, China;
b Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China;
c TianJin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300162, China

Received Date: 17 April 2009

Fund Project: the Great Program of Science Foundation of Tianjin (No.09ZCKFNC01200) and Program of Science Foundation of Tianjin (No.08JCYBJC070000).This work was supported by the National Natural Science Foundation of China (No.30873363)

In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents.Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3-yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro, KB and KBV using MTT methods in vitro.
- Podophyllotoxin derivatives,
- Chemosynthesis,
- Antitumor,
- Multidrug resistance
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