Citation: Wei Gang Huang, Jing Ya Li, Yu Luo, Jia Li, Wei Lu. Synthesis of tanshinone ⅡA analogues and their inhibitory activities against Cdc25 phosphatases[J]. Chinese Chemical Letters, ;2009, 20(12): 1461-1464. doi: 10.1016/j.cclet.2009.07.008
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Two series of tanshinone ⅡA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors.Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line,producing IC50 values in very low micromolar range.At last, the preliminary SAR was discussed.
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Keywords:
- Tanshinone ⅡA,
- Cdc25 phosphatases,
- Synthesis,
- Antitumor
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