Citation: Shu Zhang, Yi Chen, Jian An Liu, Shao Xiang Xiong, Guang Hui Wang, Jun Chen, Guo Qiang Yang. New matrix of MALDI-TOF MS for analysis of small molecules[J]. Chinese Chemical Letters, ;2009, 20(12): 1495-1497. doi: 10.1016/j.cclet.2009.06.031 shu

New matrix of MALDI-TOF MS for analysis of small molecules

a Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 7 April 2009

Fund Project: SinoGerman Center for Research Promotion (No.GZ364) and CAS (No.KJCX2-YW-H11).MOST (No.2007CB714504)The work was supported financially by NSFC (Nos.90717120 and 20435030)

New matrix, metal-phthalocyanine (MPc), of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for analysis of small molecules (usually < 500 Da).By using MPcs as matrices, small molecular samples were moved to high mass-to-charge region where there was no interference caused by the traditional matrices.The mass of the target analyte was obtained by simple calculation.
- MALDI-TOF MS,
- Small molecules,
- Metal-phthalocyanines,
- New matrix
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