Citation: Chun Mei Fu, Hong Yu Shi, Guang Sheng Qian, Zhang Wan Li. Preparation of novel chiral stationary phase based on click chemistry for ligand exchange chromatography[J]. Chinese Chemical Letters, ;2009, 20(11): 1345-1347. doi: 10.1016/j.cclet.2009.05.011 shu

Preparation of novel chiral stationary phase based on click chemistry for ligand exchange chromatography

a West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
b Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
c Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received Date: 11 March 2009

Fund Project: We thank professor Tian Bao Huang and Yuan De Long (Chengdu Institute of Organic ChemistryChinese Academy of Sciences) for the selfless assistance in the experimental work.

Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase (denoted as click-CSP) for ligand exchange chromatography. The developed protocol combines the benefits of operational simplicity, exceptionally mild conditions and high surface loadings. The enantioselectivity α of some DL-amino acids on the click- CSP were found to be in the range from 1.13 to 3.46. The chromatographic resolutions of some DL-amino acids and the stability study firmly illustrate the potential of click chemistry for preparation chiral stationary phase for ligand exchange chromatography.
- Click chemistry,
- Ligand exchange chromatography,
- Chiral stationary phase,
- DL-amino acids
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