Citation: Ke Xin Huang, Jing Xu Gong, Wei Xiong, Lei Xiang Yang, Feng Wang, Qiao Feng Tao, Yi Hang Wu, Xiao Kun Li, Joachim Stöckigt, Yu Zhao, Jia Qu. Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties[J]. Chinese Chemical Letters, ;2009, 20(9): 1030-1033. doi: 10.1016/j.cclet.2009.05.009 shu

Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties

a Key Laboratory of Southern Zhejiang TCM R&D, Pharmacy School of Wenzhou Medical College, Wenzhou 325035, China;
b Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;
c Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Received 30 October 2008

Received Date: 30 October 2008

Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups (1-12) were designed and synthesized. The antioxidative properties of these compounds were evaluated. The modified silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin, with exception of the trimethoxylated ester (5) and the aliphatic one (9). Compounds 3, 5, 7, 8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner.
- Silybin derivatives,
- Antioxidant,
- Lipid peroxidation,
- DNA cleavage
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