Citation: Xue Hui Zhang, Hong Yu, Wu Zhong, Li Li Wang, Song Li. Structure-based design, synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents[J]. Chinese Chemical Letters, ;2009, 20(9): 1019-1022. doi: 10.1016/j.cclet.2009.04.018 shu

Structure-based design, synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents

Xue Hui Zhang ^a, ,
Hong Yu ^b ,
Wu Zhong ^a ,
Li Li Wang ^a ,
Song Li ^a

a Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;
b Drug Evaluation Center of State Food and Drug Administration, Beijing 100038, China

Received Date: 24 December 2008

Fund Project: This work was supported by the National Basic Research Program of China (No.2004CB518908) and the National High Technology Research and Development Program of China (No.2006AA020601).

Mycobacterium tuberculosis FabH, an essential enzyme in mycolic acids biosynthetic pathway, is an attractive target for novel anti-tuberculosis agents. Structure-based design, synthesis of novel inhibitors of mtFabH was reported in this paper. A novel scaffold structure was designed, and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized.
- Structure-based design,
- Synthesis,
- Enzyme inhibitor,
- Mycobacterium tuberculosis FabH
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