Citation: Yong Zhang, M. Naseer A. Khan, Ping Gong, Yong Sup Lee. A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid[J]. Chinese Chemical Letters, ;2009, 20(8): 898-900. doi: 10.1016/j.cclet.2009.03.032 shu

A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China;
b Kyung Hee East-West Pharmaceutical Research Institute and Department of Pharmaceutical Sciences, College of Pharmacy, Kyunghee University, Seoul 130-701, Republic of Korea

Received Date: 19 November 2008

Fund Project: This research was supported by the Seoul Research and Business Development Program (No.10524). One of the authors M.N.A. Khan is a recipient of Post-Doctoral fellowship from the post-BK21 program, Korea.

A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl) butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.
- 2-Hydroxy-4-oxo-4-phenylbutanoates,
- Malic acid,
- Friedel-Crafts reaction
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