Citation: D. Shobha, M. Adharvana Chari K. H. Ahn. An efficient Biginelli one-pot synthesis of new benzoxazolesubstituted dihydropyrimidinones and thiones catalysed by trifluoro acetic acid under solvent-free conditions[J]. Chinese Chemical Letters, ;2009, 20(9): 1059-1061. doi: 10.1016/j.cclet.2009.03.024 shu

An efficient Biginelli one-pot synthesis of new benzoxazolesubstituted dihydropyrimidinones and thiones catalysed by trifluoro acetic acid under solvent-free conditions

Department of Applied Chemistry, Kyung Hee University, Suwon, Yongin-si, South Korea

Received Date: 8 January 2009

An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones (DHPMs) using trifluoro acetic acid as the catalyst for the first time from an aldehyde, b-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-91%) and short reaction time (40-130 min) at reflux temperature.
- Dihydropyrimidinones,
- Trifluoro acetic acid,
- Benzoxazole-substituted urea and thiourea
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