Citation: Li Jun Li, Si Guang Li, Hai Yan Li, Zhuo Cai, Hao Cheng. Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography[J]. Chinese Chemical Letters, ;2009, 20(1): 84-87. doi: 10.1016/j.cclet.2008.10.014 shu

Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography

Li Jun Li ^a, ,
Si Guang Li ^b ,
Hai Yan Li ^c ,
Zhuo Cai ^b ,
Hao Cheng ^a

a Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006, China;
b College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;
c Zhongshan School of Medicine, Sun-Yat-Sen University, Guangzhou 510080, China

Received Date: 17 June 2008

Fund Project: This project was supported by the Guangxi Provincial Foundation of Natural Science (No. 0481019).

A sensitive method for the determination of ephedrine and codeine in human urine by capillary electrophoresis (CE) was described. In order to improve the sensitivity, two online concentration techniques including cation-selective exhaustive injection (CSEI) and sweeping micellar electrokinetic chromatography (sweeping-MEKC) were used. Under the optimum conditions, the detection limits (S/N=3) were 0.10 μg/L for ephedrine and 0.80 μg/L for codeine. This method was successfully applied to real urine sample analysis.
- Cation-selective exhaustive injection,
- Sweeping micellar electrokinetic chromatography,
- Ephedrine,
- Codeine
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