Citation: Ai Wu Pan, Bei Bei Wu, Jian Min Wu. Chitosan nanoparticles crosslinked by glycidoxypropyltrimethoxysilane for pH triggered release of protein[J]. Chinese Chemical Letters, ;2009, 20(1): 79-83. doi: 10.1016/j.cclet.2008.10.012 shu

Chitosan nanoparticles crosslinked by glycidoxypropyltrimethoxysilane for pH triggered release of protein

a Department of Chemistry, Zhejiang University, Hangzhou 310027, China;
b Hospital of Zhejiang University, Hangzhou 310058, China

Received Date: 24 June 2008

pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate (TPP) and glycidoxypropyltrimethoxysilane (GPTMS). Compared with TPP crosslinked chitosan particles, the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range. Fluorescein isothiocyanate (FITC) labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pHresponsive drug delivery materials.
- Chitosan,
- Nanoparticles,
- pH-response,
- Drug delivery,
- Controlled release,
- Protein
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